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Marco Ratto Sensitivity Analysis in Practice


Sensitivity analysis should be considered a pre-requisite for statistical model building in any scientific discipline where modelling takes place. For a non-expert, choosing the method of analysis for their model is complex, and depends on a number of factors. This book guides the non-expert through their problem in order to enable them to choose and apply the most appropriate method. It offers a review of the state-of-the-art in sensitivity analysis, and is suitable for a wide range of practitioners. It is focussed on the use of SIMLAB – a widely distributed freely-available sensitivity analysis software package developed by the authors – for solving problems in sensitivity analysis of statistical models. Other key features: Provides an accessible overview of the current most widely used methods for sensitivity analysis. Opens with a detailed worked example to explain the motivation behind the book. Includes a range of examples to help illustrate the concepts discussed. Focuses on implementation of the methods in the software SIMLAB – a freely-available sensitivity analysis software package developed by the authors. Contains a large number of references to sources for further reading. Authored by the leading authorities on sensitivity analysis.

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David Beaver I. Sense and Sensitivity


Sense and Sensitivity advances a novel research proposal in the nascent field of formal pragmatics, exploring in detail the semantics and pragmatics of focus in natural language discourse. The authors develop a new account of focus sensitivity, and show that what has hitherto been regarded as a uniform phenomenon in fact results from three different mechanisms. The book Makes a major contribution to ongoing research in the area of focus sensitivity – a field exploring interactions between sound and meaning, specifically the dependency some words have on the effects of focus, such as «she only LIKES me» (i.e. nothing deeper) compared to «she only likes ME» (i.e. nobody else) Discusses the features of the QFC theory (Quasi association, Free association, and Conventional association), a new account of focus implying a tripartite typology of focus-sensitive expressions Presents novel cross-linguistic data on focus and focus sensitivity that will be relevant across a range of linguistic sub-fields: semantics and pragmatics, syntax, and intonational phonology Concludes with a case study of exclusives (like “only”), arguing that the entire existing literature has missed crucial generalizations, and for the first time explaining the focus sensitivity of these expressions in terms of their meaning and discourse function

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Jessica Cariboni Global Sensitivity Analysis


Complex mathematical and computational models are used in all areas of society and technology and yet model based science is increasingly contested or refuted, especially when models are applied to controversial themes in domains such as health, the environment or the economy. More stringent standards of proofs are demanded from model-based numbers, especially when these numbers represent potential financial losses, threats to human health or the state of the environment. Quantitative sensitivity analysis is generally agreed to be one such standard. Mathematical models are good at mapping assumptions into inferences. A modeller makes assumptions about laws pertaining to the system, about its status and a plethora of other, often arcane, system variables and internal model settings. To what extent can we rely on the model-based inference when most of these assumptions are fraught with uncertainties? Global Sensitivity Analysis offers an accessible treatment of such problems via quantitative sensitivity analysis, beginning with the first principles and guiding the reader through the full range of recommended practices with a rich set of solved exercises. The text explains the motivation for sensitivity analysis, reviews the required statistical concepts, and provides a guide to potential applications. The book: Provides a self-contained treatment of the subject, allowing readers to learn and practice global sensitivity analysis without further materials. Presents ways to frame the analysis, interpret its results, and avoid potential pitfalls. Features numerous exercises and solved problems to help illustrate the applications. Is authored by leading sensitivity analysis practitioners, combining a range of disciplinary backgrounds. Postgraduate students and practitioners in a wide range of subjects, including statistics, mathematics, engineering, physics, chemistry, environmental sciences, biology, toxicology, actuarial sciences, and econometrics will find much of use here. This book will prove equally valuable to engineers working on risk analysis and to financial analysts concerned with pricing and hedging.

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Arcam - A19 (Discontinued) - Integrated Amplifier

Input sensitivity at 1kHz: 5mV; Input impedance: 47kΩ + 100pF; Frequency response (ref. RIAA curve): 20Hz—20kHz ± 1dB; Signal/noise ratio (Awtd) 50W, ref. 5mV input: 80dB; Overload margin, 50mV at 1kHz: 20dB

Comparison of the sensitivity and specificity of the CA19 ...

The sensitivity of CA19-9 (>75 U/ml) in detecting cancer was greater than that of CEA (>5 ng/ml) (86.5% vs. 48.4%) (p < 0.01, McNemar test). The sensitivity of CA19-9 was 78.6% in resectable and 91.3% in unresectable disease. The specificity of CA19-9 was also greater than CEA (92.5% vs. 87.3%), although this difference was not statistically significant. The higher the CA19-9 or CEA level, the ...

Comparison of the sensitivity and specificity of the CA19 ...

The sensitivity of CA19-9 (greater than 75 U/ml) in detecting cancer was greater than that of CEA (greater than 5 ng/ml) (86.5% vs. 48.4%) (p less than 0.01, McNemar test). The sensitivity of CA19-9 was 78.6% in resectable and 91.3% in unresectable disease. The specificity of CA19-9 was also greater than CEA (92.5% vs. 87.3%), although this difference was not statistically significant. The ...

Sensitivity and specificity - Wikipedia

Sensitivity and specificity are statistical measures of the performance of a binary classification test that are widely used in medicine: . Sensitivity measures the proportion of positives that are correctly identified (i.e. the proportion of those who have some condition (affected) who are correctly identified as having the condition). ...

Sensitivity Definition

Sensitivity analysis is also conducted on a micro level. A company may want to know the sensitivity of its revenues to a product price change, for example. Example: Bond Sensitivity . Fixed-income ...

Clinical tests: sensitivity and specificity | BJA ...

The sensitivity and specificity of a quantitative test are dependent on the cut-off value above or below which the test is positive. In general, the higher the sensitivity, the lower the specificity, and vice versa. Receiver operator characteristic curves are a plot of false positives against true positives for all cut-off values. The area under the curve of a perfect test is 1.0 and that of a ...

Sensitivity and specificity analysis | Statistical ...

Sensitivity (equivalent to the True Positive Rate): Proportion of positive cases that are well detected by the test. In other words, the sensitivity measures how the test is effective when used on positive individuals. The test is perfect for positive individuals when sensitivity is 1, equivalent to a random draw when sensitivity is 0.5. If it is below 0.5, the test is counter-performing and ...

Introduction: Sensitivity Analysis

Sensitivity Auditing, Risk Assessment, Impact Assessment Introduction In many elds such as environmental risk assessment, behavior of agronomic systems, structural reliability or operational safety, mathematical models are used for simula-tion, when experiments are too expensive or impracticable, and for prediction. Models are also used for uncertainty quanti cation and sensitivity analysis ...

Sensitivity Calculator | Diagnostic Test Evaluation Calculator

Sensitivity: It is also defined as true positive rate. Sensitivity analysis is made in diagnostic test evaluation methods. It is a high sensitivity test that measures the true proportion of patients with disease. Positive cases are classified as true positives (sick people correctly identified as sick) and false positives (healthy people incorrectly identified as sick). Diagnostic Test ...

Investigation on the sensitivity of flexible foundation ...

The turbulence intensity is selected as level A (19.86% at hub). In accordance with IEC-64000-1, ... In this study, the sensitivity of foundation models to the dynamic behaviour of an offshore wind turbine under earthquake loadings has been investigated. In order to consider the influence of flexible foundation and earthquake loading, SAF is developed and implemented in an open source tool ...

A new mechanism for reduced sensitivity to demethylation ...

A new mechanism for reduced sensitivity to demethylation‐inhibitor fungicides in the fungal banana black Sigatoka pathogen Pseudocercospora fijiensis. Caucasella Diaz-Trujillo, Pablo Chong, Ioannis Stergiopoulos, Viviane Cordovez, Mauricio Guzman, Pierre J. G. M. de Wit, H.J.G. Meijer, Gabriel Scalliet, Helge Sierotzki, Esther Lilia Peralta, Rafael E. Arango Isaza (Corresponding author), G.H ...

Sensitivity Versus Detection Limit - PerkinElmer

Sensitivity is a measure only of signal magnitude, the solution concentration or weight of an element that produces a signal of 0.0044A (1%A) for continuous or peak height measurements or 0.0044 A•s for integrated peak area. It is also known as characteristic concentration with flame AA or characteristic mass with furnace AA. Technical noTe Atomic Absorption Sensitivity Versus Detection ...

Sensitivity Analysis 3

the sensitivity of a solution to changes in the data gives us insight into possible technological improvements in the process being modeled. For instance, it might be that the available resources are not balanced properly and the primary issue is not to resolve the most effective allocation of these resources, but to investigate what additional resources should be acquired to eliminate ...

Sensitivity and Specificity | Epidemiology | Microbe Notes

Sensitivity and Specificity. When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results obtained are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow its evaluation. Therefore, when evaluating diagnostic tests, it is important to calculate the ...

Sensitivity - Wikipedia

Sensitivity of a transducer, the relationship between input and output power; Mathematics. Sensitivity (control systems), variations in process dynamics and control systems; Sensitivity analysis, apportionment of the uncertainty in the output of a mathematical model among its inputs; Sensitivity and specificity, statistical measures of the performance of binary classification tests; Other uses ...

Sensitivity Analysis: Meaning, Uses, Methods of measurement

Sensitivity analysis works on the simple principle: Change the model and observe the behavior. The parameters that one needs to note while doing the above are: A) Experimental design: It includes combination of parameters that are to be varied. This includes a check on which and how many parameters need to vary at a given point in time, assigning values (maximum and minimum levels) before the ...

PET Performance Measurements Using the NEMA NU 2-2001 ...

Therefore, the most significant change in the NU 2-2001 standard, compared with the NU 2-1994 standard, is the change from a 19-cm-long phantom to a 70-cm-long phantom (albeit with a line source) for several of the tests, including sensitivity, scatter fraction, counting rate performance, and count loss correction. The 70-cm-long phantom is a better approximation to the activity distribution ...

Ecological gifts: assessing ecological sensitivity - Canada.ca

A19. Areas designated for biodiversity purposes by regional agencies such as the Niagara Parks Commission, St. Clair Parkway Commission, St. Lawrence Parks Commission and the Waterfront Regeneration Trust. B. General Criteria for Other Ecologically Sensitive Lands . Lands, easements or covenants relative to such lands, that meet one or more of the following general criteria may also be ...

Sense and Sensibility - Chapter 19 - Jane Austen

Chapter 19. E dward remained a week at the cottage; he was earnestly pressed by Mrs. Dashwood to stay longer; but as if he were bent only on self-mortification, he seemed resolved to be gone when his enjoyment among his friends was at the height. His spirits, during the last two or three days, though still very unequal, were greatly improved -- he grew more and more partial to the house and ...

Figure 19 from A STUDY ON THE SENSITIVITY ANALYSIS OF THE ...

DOI: 10.21278/BROD68401 Corpus ID: 36547327. A STUDY ON THE SENSITIVITY ANALYSIS OF THE HYDRODYNAMIC DERIVATIVES ON THE MANEUVERABILITY OF KVLCC2 IN SHALLOW WATER @article{Kim2017ASO, title={A STUDY ON THE SENSITIVITY ANALYSIS OF THE HYDRODYNAMIC DERIVATIVES ON THE MANEUVERABILITY OF KVLCC2 IN SHALLOW WATER}, author={D. Kim and S. Kim and Su-Jeong Kim and Kwang-Jun Paik}, journal={Brodogradnja ...

The Use of Procalcitonin as a Sepsis Marker in a Community ...

From the 165 sepsis cases who had positive blood cultures, PCT had a sensitivity of 89.7%. In comparison, lactic acid's sensitivity at the current cutoff of 18.02 mg/dL (2.0 mmol/L) was 64.9%. There was a 32% decrease in median cost before and after PCT implementation, even with the length of stay remaining at 5 days in both time periods.

Introduction: Sensitivity Analysis

sensitivity auditing, a new discipline that tests the entire inferential chain including model development, implicit assumptions and normative issues, and which is recom-mended when the inference provided by the model needs to feed into a regulatory or policy process. For the \Sensitivity Analysis" chapter, in addition to this introduction, nine papers have been written by around twenty ...

Rapid Testing - IDSA

Given the higher sensitivity with RT-PCR in this sample type, these findings may limit generalizability to settings where only nasopharyngeal swabs are u s ed. Overall, in 130 upper and lower tract specimens in patients with suspected SARS-CoV-2, a rapid RT-LAMP assay was associated with high specificity and sensitivity for SARS-CoV-2 detection.

Sensitivity - definition of sensitivity by The Free Dictionary

Define sensitivity. sensitivity synonyms, sensitivity pronunciation, sensitivity translation, English dictionary definition of sensitivity. ability to react to stimuli: sensitivity to light Not to be confused with: sensibility – capacity for feeling; responsiveness: She has a great sensibility... Sensitivity - definition of sensitivity by The Free Dictionary. https://www.thefreedictionary ...

OSA | Dynamic range and sensitivity requirements of ...

Such noises would impact the sensitivity to resolve small Chl changes. For example, around 0.1 mg m − 3, MERIS-FR cannot resolve a 19.4% relative change in Chl (corresponding to 0.019 mg m − 3), while MODISA may resolve changes of > 4.8 % (0.0048 mg m − 3). Clearly, different SNRs from various ocean color sensors would lead to varying ...

Membrane fluidity determines sensitivity of filamentous ...

Our findings provide a method to predict the sensitivity of a fungus to chitosan based on its plasma membrane composition, and suggests a new strategy for antifungal therapy, which involves treatments that increase plasma membrane fluidity to make fungi more sensitive to fungicides such as chitosan. Introduction. Chitosan is a partly deacetylated form of chitin, the β‐(1,4)‐ d ‐linked ...

Increased Insulin Sensitivity and Obesity Resistance in ...

Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP-1B+/+ littermates.

Sensitivity | Definition of Sensitivity at Dictionary.com

Sensitivity definition, the state or quality of being sensitive; sensitiveness. See more.

What is Sensitivity Analysis? - MATLAB & Simulink

What is Sensitivity Analysis? Sensitivity analysis is defined as the study of how uncertainty in the output of a model can be attributed to different sources of uncertainty in the model input.In the context of using Simulink ® Design Optimization™ software, sensitivity analysis refers to understanding how the parameters and states (optimization design variables) of a Simulink model ...

Sensitivity Analysis - Default

Sensitivity Analysis . Sensitivity analysis in a method used to incorporate uncertainty into decision making by taking each uncertain factor in turn, and calculates the change that would be necessary in that factor before the original decision is reversed. Typically, it involves posing 'what-if' questions. By using this technique it is possible to establish which estimates (variables) are more ...

Sensitivity Analysis Definition

What-If Calculation: Calculations for testing a financial model using different assumptions and scenarios. What-if`calculations enable the forecaster to check the variance in end results for a ...

Sensitivity Analysis (Definition, Formula) | How to Calculate?

Sensitivity analysis is an analysis technique that works on the basis of what-if analysis like how independent factors can affect the dependent factor and is used to predict the outcome when analysis is performed under certain conditions. It is commonly used by investors who takes into consideration the conditions that affect their potential investment to test, predict and evaluate result ...

The Conundrum of Gluten Sensitivity: Why the Tests are ...

Many of us believe that the toxic peptides of gluten found in wheat, rye and barley may detrimentally affect any tissue in the body and are not restricted to the intestines. As a matter-of-fact, one of the ‘mantras’ of the Gluten Sensitivity Network comes from an 8-year old article: “That gluten sensitivity is regarded as principally a disease of the small bowel is a historical ...

An Introduction to Sensitivity Analysis

sensitivity analysis is often impossible.3 The modeler must pick the parameters he expects to have most influence on the behavior, or the ones that he is most uncertain about, and only use those in the sensitivity analysis. We will see in the second exploration that an examination of the structure of the model can indicate, without running the sensitivity tests, what kind of effect changes in ...

The International Criteria for Behçet's Disease (ICBD): a ...

Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD‐mimicking diseases or presenting at least one major BD sign.

Future of Floods | Engineering ecology into Portsmouth sea ...

“The significant nature and sensitivities of the harbour is another challenge,” Timlett says. “We have to be careful we don’t have a detrimental impact – we’ve had to apply a silt curtain to make sure we don’t have any sediment going out into the water and we change piling techniques in the summer so we don’t aggravate the seal pups.

sensitivity - LEO: Übersetzung im Englisch ⇔ Deutsch ...

Lernen Sie die Übersetzung für 'sensitivity' in LEOs Englisch ⇔ Deutsch Wörterbuch. Mit Flexionstabellen der verschiedenen Fälle und Zeiten Aussprache und relevante Diskussionen Kostenloser Vokabeltrainer

[PDF] Sensitivity and specificity of CA-19-9 for the ...

Analysis with ROC curves was performed to identify sensitivity and specificity at the different cutting points. Patients and methods: We included 54 patients with a diagnosis of obstructive-origin jaundice. They were divided in two groups according to the final diagnosis, malignant disease vs. benign disease. Serum CA 19-9 was determined at admittance and once cholestasis had been resolved ...

Sense and Sensibility Chapter 19 Summary & Analysis ...

Need help with Chapter 19 in Jane Austen's Sense and Sensibility? Check out our revolutionary side-by-side summary and analysis.

Variability of insulin sensitivity during the first 4 days ...

Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control | springermedizin.de Skip to main content Registrieren Login Mein Profil

(PDF) A method of increasing the sensitivity for laser ...

The work pre- sented here demonstrates that the sensitivity of this barrier to entry into the trap, and the trapping well is method can be increased significantly by firing the not very deep. During the time that the ion is travers- laser and injecting ions into the trap, on the rising edge ing the trap (lo-50 ps, based on both modeling stud- of the RF waveform, before the RF potential is ...

Sensitivity analysis financial definition of sensitivity ...

sensitivity analysis a means of testing the extent to which the results of an analysis of an INVESTMENT project or company budget would change if one or more of the assumptions on which the analysis is based were to change. For example, in estimating the rate of return on an investment, such as a new machine, a firm will need to input various assumptions about the cost of the machine, the ...

Do nitrogen additions change the sensitivity of detached ...

The results are consistent with the nutritional status of the foliage at the time of sampling.}, author = {Sheppard, L J and Rosengren, Ulrika and Emmett, B A}, issn = {0282-7581}, language = {eng}, number = {6}, pages = {487--498}, publisher = {Taylor & Francis}, series = {Scandinavian Journal of Forest Research}, title = {Do nitrogen additions change the sensitivity of detached shoots from ...

Sensitivity analysis allows for the definition of a stable ...

A sensitivity analysis provides information on the degree to which a design parameter must be changed in order to achieve a desired quality level. If the influence and sensitivity of a design parameter is known, a better choice can be made on the particular parameter’s value. By showing which design parameter (input) influences the quality (output) and to what extent this occurs, the forming ...

Rajnath Singh holds telephonic conversation with Japanese ...

A 19-year-old woman allegedly ended her life by hanging herself in the Madavara area here, police said on Monday. The body of the woman was found hanging from the ceiling of her room on Saturday, Station House Officer, Madawara police stati...

Science in the Age of Sensibility | Department of History

Empiricism today implies the dispassionate scrutiny of facts. But Jessica Riskin finds that in the French Enlightenment, empiricism was intimately bound up with sensibility. In what she calls a "sentimental empiricism," natural knowledge was taken to rest on a blend of experience and emotion. Riskin argues that sentimental empiricism brought together ideas and institutions,

Sensitivity analysis: MedlinePlus Medical Encyclopedia

Sensitivity tests are important in helping find the right antibiotic for you. Your provider may start you on one antibiotic, but later change you to another because of the results of sensitivity analysis. What Abnormal Results Mean. If the organism shows resistance to the antibiotics used in the test, those antibiotics will not be effective treatment. Risks. Risks depend on the method used to ...

Sensitivity Analysis | SpringerLink

Abstract. The chapter begins by defining sensitivity in projects, whatever their nature. The main word here is uncertainty, because no matter the kind of project, there is always uncertain data and predictions, vague information, unexpected people or stakeholder reactions, deviations in prices, labor performance different from estimated, etc. Sensitivity analysis is designed to examine the ...

Overview of Sensitivity Analysis - What is Sensitivity ...

Sensitivity Analysis is a tool used in financial modeling What is Financial Modeling Financial modeling is performed in Excel to forecast a company's financial performance. Overview of what is financial modeling, how & why to build a model. to analyze how the different values of a set of independent variables affect a specific dependent variable under certain specific conditions. In general ...

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W. Congrave Description of the construction, properties, and varieties of the hydro-pneumatic lock


Полный вариант заголовка: «Description of the construction, properties, and varieties of the hydro-pneumatic lock : shewing the principles of its action, with introductory observations on locks in general, and a supplement containing the demonstration of the spontaneous adjustments of which it is capable, so that its operations may in no way be affected by any possible variations in the canal levels / invented by colonel Congrave».

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Prouzet Patrick Vulnerability of Coastal Ecosystems and Adaptation


The vulnerability of socio -ecosystem combines the probability of exposure to natural or anthropogenic pressure, sensitivity and resilience. This book presents a systemic view of the diversity of pressures and impacts produced by climate change and human actions. Erosion of biodiversity by changing ocean chemistry, the intensification of global change raises the problem of the adaptation of living resources.

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